What to know about mifepristone, the abortion pill the Supreme Court just ruled to protect (2024)

Updated ·4 min read

The Supreme Court ruled unanimously on Thursday to protect access to mifepristone, one of two drugs used in the majority of medication abortions. Access to mifepristone has been on shaky ground since the overturning in 2022 of Roe v. Wade, the Supreme Court ruling that protected access to abortion in the United States.

According to the Guttmacher Institute, medication abortion is the most common abortion method in the U.S., surpassing surgical abortions for the first time in 2020. Mifepristone is currently in the middle of a political tug-of-war, with some conservative states seeking to restrict or eliminate access to the abortion pill, while other states are trying to protect and expand access. Also, the Biden administration has recently allowed certified pharmacies to dispense medication abortion. Here’s what you need to know.

💊 What is mifepristone?

Mifepristone is a medication that effectively blocks the hormone progesterone and can be used, in combination with misoprostol, to end a pregnancy up to the first 10 weeks of gestation. “When someone first gets pregnant, there are a lot of changes in hormones, and one of the most important hormones at the beginning of a pregnancy is progesterone,” Dr. Jessica Shepherd, an ob-gyn, tells Yahoo Life. Shepherd explains that progesterone helps sustain a pregnancy, while mifepristone has “an anti-progesterone effect,” essentially blocking the hormone “from doing what it needs to do early in pregnancy, so it can’t sustain the pregnancy.”

Mifepristone is “exceptionally safe,” says Shepherd, noting that the drug has been approved by the Food and Drug Administration since 2000. “It’s been used for decades,” she notes. “It’s approved in nearly 100 countries.” Women’s health expert Dr. Jennifer Wider agrees, telling Yahoo Life, "Many, many studies have fully established the safety and efficacy of mifepristone.”

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🏥 What’s happening with CVS and Walgreens selling abortion pills?

On March 1, CVS and Walgreens — two of the largest pharmacy chains in the U.S. — announced that they would soon start selling mifepristone via a prescription in states where it’s legal to do so. Walgreens is now dispensing the medication at select certified locations in more than 20 states. CVS Health locations in select states, including Rhode Island and Massachusetts, are also currently dispensing mifepristone.

The Biden administration called the move “an important milestone in ensuring access to mifepristone.” Many experts applaud the decision. “I think it’s good news and helps ensure women’s reproductive rights,” says Wider. Shepherd says that the move clearly shows that Walgreens and CVS are “making a stance toward, how can we get women the care they need? It’s so imperative and so overdue. I look forward to seeing where it’s going and am hopeful it will expand to other states as well.”

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⚖️ What’s happening with the Supreme Court and mifepristone?

After a federal judge in Texas ruled to suspend the FDA’s approval of mifepristone in April 2023, which would have pulled the drug off the market, there’s been an ongoing legal battle over access to the medication. In August 2023, an appeals court in New Orleans upheld some restrictions to the abortion pill — essentially banning telemedicine prescriptions and mail delivery of mifepristone. However, that ruling was put on hold until the Supreme Court could weigh in, allowing in the meantime access to the drug in states where abortion is legal.

On Dec. 13, 2023, the Supreme Court agreed to hear appeals from the Biden administration and mifepristone manufacturer Danco Labs, both of which sought to reverse those restrictions. The court started hearing arguments on March 26, marking the first time Supreme Court justices weighed in on abortion since overturning Roe nearly two years ago. On June 13, justices ruled unanimously to protect access to mifepristone. The justices ruled that the groups who brought the case against mifepristone had no legal standing to sue over the FDA's approval of mifepristone, the Associated Press reported.

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🛎️ Why it matters

Experts say that patients should have access to mifepristone, with Shepherd calling it a “reproductive justice issue.” She notes that “obstacles have been put in the way” of abortion access in states with restrictions and that access to the medication provides “ways for people to make decisions for themselves.”

Wider agrees, saying: “Access to mifepristone is very important because its use accounts for more than half of medical terminations across the country, and it’s safe and effective.” She adds: “It allows women to make these choices without putting themselves at risk.”

This article was originally published on March 1, 2024, and has been updated.

What to know about mifepristone, the abortion pill the Supreme Court just ruled to protect (2024)

FAQs

What to know about mifepristone, the abortion pill the Supreme Court just ruled to protect? ›

SUPREME COURT OF THE UNITED STATES

What was the Supreme Court decision on the abortion pill? ›

The Supreme Court unanimously rejected a lawsuit challenging the Food and Drug Administration's approach to regulating the abortion pill mifepristone, allowing the drug to stay on the market. The court ruled that the doctors and anti-abortion groups that had challenged access to the drug did not have standing to sue.

What are the negative effects of mifepristone? ›

You should also call your doctor immediately or get emergency medical treatment if you have general symptoms of illness such as weakness, nausea, vomiting, diarrhea, or feeling sick for more than 24 hours after taking mifepristone even if you do not have a fever or pain in the area below your waist.

Can misoprostol damage the womb? ›

Misoprostol use in pregnancy might increase the chance for preterm delivery (birth before week 37), poor growth (baby smaller than expected) uterine rupture, and meconium passage in the uterus. Meconium is the name for the first bowl movement that a newborn has.

What did Roe v. Wade protect? ›

The Supreme Court's ruling in Roe v. Wade on January 22, 1973, decriminalized abortion nationwide. It protected the right to access abortion legally all across the country, and freed many patients to access the care they needed when they needed it — without fear.

What did the Supreme Court decide about abortion in 1973? ›

On January 22, 1973, the Supreme Court struck down Texas's criminal ban on abortion and held that the right to abortion is a “fundamental right.”1 In the 7–2 opinion, the Court held that, along with decisions relating to marriage, contraception, education, and family relationships, the decision about whether to ...

How does mifepristone affect the uterus? ›

Mifepristone is used in a regimen together with misoprostol to end a pregnancy that is less than 70 days in duration. It works by stopping the supply of hormones that maintains the interior of the uterus. Without these hormones, the uterus cannot support the pregnancy and the contents of the uterus are expelled.

What does misoprostol do to the body? ›

Misoprostol is used to decrease the chance of having stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin. This medicine works by helping the stomach protect itself against acid damage, and decreases the amount of acid produced by the stomach.

What interferes with mifepristone? ›

Some products that may interact with this drug include: long-term corticosteroid therapy (such as, prednisone), other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).

How do you know if your uterus is damaged? ›

Some common symptoms of uterine problems include: Pain in the uterine region. Abnormal or heavy vagin*l bleeding. Irregular menstrual cycle.

Which of the following is a serious side effect of misoprostol? ›

Tell your doctor right away if you develop any of these serious signs of dehydration and mineral imbalance: dizziness, decreased urination, mental/mood changes, muscle weakness, slow/irregular heartbeat.

What are the danger signs of misoprostol? ›

Incidence not known
  • Bladder pain.
  • bloody nose.
  • bloody or black, tarry stools.
  • bloody or cloudy urine.
  • blurred vision.
  • body aches or pain.
  • chest pain.
  • chills.
Feb 1, 2024

What does overturning Roe v. Wade mean? ›

The overturning of Roe v. Wade means women's ability to choose to have an abortion or continue a pregnancy is no longer protected by the constitution of the Unites States (Rohan, Editorial: Overturning Roe v. Wade: What are the implications for perinatal nurses?, 2021).

What was Roe's argument? ›

In her lawsuit, Roe alleged that the state laws were unconstitutionally vague and abridged her right of personal privacy, protected by the First, Fourth, Fifth, Ninth, and Fourteenth Amendments.

Is there still a constitutional right to privacy? ›

Life, liberty, and privacy. These inalienable rights are enshrined in Article I, Section 1 of the California Constitution.

Does mifepristone affect mood? ›

Mifepristone blocks progesterone, glucocorticoid and androgen receptors. Anxiolytic-like effects have been observed following acute administration. Antidepressant-like effects have been demonstrated following chronic administration.

What are the worst side effects of misoprostol? ›

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects.

Does mifepristone affect liver? ›

Severity of liver injury during mifepristone therapy ranges from asymptomatic elevations in serum aminotransferase levels to symptomatic liver injury with jaundice.

What is the failure rate of mifepristone? ›

Recent evidence suggests that true drug failures accounted for only about 50% of the surgical interventions. It is suggested that the failure rate of mifepristone and misoprostol may be as low as 2%. Failures in user choice can be reduced with improved counseling.

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